Friday, April 27, 2012

Meet Dr. Karl Anderson

Karl E. Anderson, M.D.
Professor, Division of Gastroenterology and Hepatology

Karl E. Anderson, M.D.
Karl E. Anderson, M.D.
Professor of Preventive Medicine and Community Health
Internal Medicine, and Pharmacology and Toxicology
University of Texas Medical Branch
301 University Blvd.
Galveston, TX 77555-1109
A graduate of the Johns Hopkins University School of Medicine, Dr. Anderson completed his residency and postgraduate training in gastroenterology at the New York Hospital-Cornell Medical Center. He was a member of the faculty at the Rockefeller University, Cornell University Medical College and New York Medical College before coming to UTMB in 1987. He directs the Division of Human Nutrition in the Department of Preventive Medicine and Community Health, and is an active clinical investigator particularly on the General Clinical Research Center (GCRC), where he is also Associate Program Director. He is PI for UTMB's NIH K30 grant that supports a variety of clinical research education programs, Director of the Clinical Research Education Office, and Director of the Graduate Program (PhD or MS) in Clinical Science, which is suited particularly for physicians seeking advanced training in clinical research.
Research Interests
Dr. Anderson's research interests include (i) pathogenesis of human porphyrias and identification of factors that increase susceptibility; (ii) development of new therapies for porphyrias; (iii) effects of diet on drug metabolism in humans, especially by cytochrome P450 enzymes, and on circulating hormone levels; (iv) collaborative work on effects of soy feeding in humans on breast cancer risk.
Clinical Interests
Dr. Anderson clinical interests include human porphyrias, metabolic and nutritional aspects of liver disease, and general clinical gastroenterology and hepatology.
Selected Publications
  • Egger NE, Goeger DE, Payne DA, Miskovsky EP, Weinman SA, Anderson KE. Porphyria cutanea tarda: multiplicity of risk factors including HFE mutations, hepatitis C and inherited uroporphyrinogen decarboxylase deficiency. Digestive Diseases and Sciences 2002; 47:419-426.
  • Anderson KE, Bloomer JR, Bonkovsky HL, Kushner JP, Pierach CA, Pimstone NR, Desnick RJ: Recommendations for the diagnosis and treatment of the acute porphyrias. Annals of Internal Medicine 2005;142:439-50.
  • Huang Y, Cao S, Nagamani M, Anderson KE, Grady J, Lu L-JW: Decreased circulating levels of tumor necrosis factor-alpha (TNF-a) in postmenopausal women during consumption of soy containing isoflavones. Journal of Clinical Endocrinology and Metabolism 2005;90:3956-62.
  • Nhan S, Anderson KE, Nagamani M, Grady JJ, Lu LJ: Effect of a soymilk supplement containing isoflavones on urinary f2 isoprostane levels in premenopausal women. Nutrition and Cancer 2005;53(1):73-81.
  • Akagi R, Kato N, Inoue R, Anderson KE, Jaffe EK, Sassa S: delta-Aminolevulinate dehydratase (ALAD) porphyria: The first case in North America with two novel ALAD mutations. Molecular Genetics and Metabolism. 2006:87:329-336.
  • Akagi R, Inoue R, Muranaka S, Tahara T, Taketani S, Anderson KE, Phillips JD, Sassa S. Dual gene defects involving d-aminolaevulinate dehydratase and coproporphyrinogen oxidase in a porphyria patient. British Journal of Haematology. 2006;132:237-243.
  • Anderson KE, Collins S. Open-label study of hemin for acute porphyria: clinical practice implications. American Journal of Medicine. 2006;119:19-24.
  • Anderson KE: The porphyrias (Chapter 72), in Boyer T, Wright T, Manns M (eds): Zakim and Boyer's Hepatology: A Textbook of Liver Diseases. Philadelphia, Elsevier, 2006, pp 1391-1432. 9.
  • Anderson KE, Porphyria cutanea tarda – a possible role for ascorbic acid (Editorial) Hepatology, 2007;45(1):6-8. 10.
  • Madan P, Schaaf CP, Vardhan P, Bhayana S, Chandra P, Anderson KE: Hans Gunther and his disease. Photodermatol Photoimmunol Photomed 2007;23(6):261-3.
  • Desnick RJ, Astrin KH, Anderson KE. Heme biosynthesis and the porphyrias (Chapter 28). In: Suchy, FJ, Sokol, R,J, Balistreri, WF, eds. Liver Disease in Children, 3rd edition. Cambridge: Cambridge University Press, 2007, pp 677-693.
  • Anderson KE. The porphyrias (Chapter 223). In: L. Goldman and D. Ausiello., eds. Cecil Textbook of Medicine, 23rd edition, Philadelphia, W.B. Saunders Co., 2007, pp 1585-1593.

Finding a Good Doctor

The American Porphyria Foundation promotes comprehensive care necessary for treating individuals with Porphyria.  This section of our website offers suggestions for finding a local doctor who can manage your Porphyria, options for having your doctor consult a Porphyria specialist, and information on arranging a visit to a Porphyria clinic.
Because Porphyria is so rare, few physicians have experience treating patients with the disease.  Most patients are in fact treated But the APF can help by putting your doctor's office in touch with a Porphyria specialist who can offer guidance on your care.
For those who need a diagnosis, you may be able to obtain a consultation at Porphyria clinic. Call the APF to reach a porphyria expert at a porphyria center.  The APF office will also guide you to doctors who are not experts but are knowledgeable about porphyria. You may be asked to send your blood, urine, and stool samples for evaluation in advance of a clinic appointment.  Especially if you plan to travel for a consultation, it is a good idea to call ahead and explain that you would like to be evaluated for Porphyria so that you can be sure you have done any necessary testing in advance.  If local video conferencing facilities are available, telemedicine consultation with a Porphyria expert is also available.
Regardless of your situation, it is best to establish a good relationship with a doctor in your area.  Developing a relationship with a primary care physician takes time and can be frustrating, particularly when you have difficulty finding a doctor who will manage your care.  In this section of the website, you will also find Tips for the Doctor's Office that may help.
If you're having trouble finding a local doctor, the following organizations' doctor finder or physician referral services could be helpful.  The APF does not recommend or endorse the doctors listed through these sites.
American Medical Association
American Society of Hematology
American Association for the Study of Liver Diseases
American Academy of Dermatology
If you would like to read about supporting programs to ensure the quality of specialists in the field of porphyria, please see our Protect Our Future campaign information.

Sunday, April 22, 2012

Awareness Week on Porphyria

Look at all the Donations coming In. Have you taken a moment to donate, it's all for a good cause: AMERICAN PORPHYRIA FOUNDATION Nonprofit Media Check it out at: under American Porphyria Foundation.

Raised since 2011
25 fundraisers
146 donors
Campaigns (2)
APF Pet Beauty Contest
Ends 8/30/2012

Monday, April 16, 2012

"Raising Awareness" What Does this mean to YOU?

"Raising awareness" is a phrase that advocacy groups commonly use when promoting a particular issue, organization, or event. Akin to consciousness raising, raising awareness refers to alerting the general public that a certain issue exists and should be approached the way the group desires. Common subjects include certain diseases (e.g. breast cancerAIDS), conflicts (e.g. the Darfur genocideglobal warming), movements (e.g. GreenpeacePETAEarth Hour), andpolitical parties or politicians.
The term awareness raising is also used in the Yogyakarta Principles against discriminatory attitudes[1] and LGBT stereotypes, as well as the Convention on the Rights of Persons with Disabilities to combat stereotypesprejudices, and harmful practices toward people with disabilities.[2]
Since informing the populace of a public concern is often regarded as the first step to changing how the institutions handle it, raising awareness is often the first activity any advocacy group engages in.  
With Porphyria we all have different forms, strengths and abilities so tell me what are you doing today to raise Awareness for Porphyria?  Read about it, talk about it, donate time, energy, money.  Hold a conference, inform your community, local news and TV.  Walk for a cause! Run the race if you can, you make it known to all we are all going to win if we just try.  Have a great week everyone!

Tuesday, April 3, 2012

National Porphyria Awareness Week April 22-28, 2012 is all about YOU

The challenge of living with porphyria starts with how little is known about it among friends, family and the medical community. That is why National Porphyria Awareness Week is so important. It provides each of YOU with the opportunity to enhance porphyria awareness among the public and medical professionals right where you live. Many of you helped last year, setting up at hospital Health Fairs, seminars and grand rounds, gaining newspaper and television interviews, exhibiting at conventions. Some members even created their own campaigns to advance porphyria awareness, but we need more of you to:
*Tell your story to local media. Television, newspapers, community magazines are looking for human interest stories about people who have encountered a major illness and have undertaken the challenge to help others in a similar situation. LeAnn Cook facilitated a family interview in the local newsletter about the boys EPP struggles. The Fleegel family appeared in a documentary on EPP that aired recently.
*SHARE knowledge about porphyria at your doctor’s offices and local hospitals. You might suggest that they host a seminar or grand rounds on porphyria. Some members have even set up an information table or exhibit at a health fair. Amy Chapman sold Porphyria Awareness wristbands and set up seminars for doctors in her home town and even on vacation in Bermuda. Joanna Floyd attended Health Fairs and sent emails about porphyria to nearby hospitals. Nathan Carr provided educational material about porphyria to his hospital’s medical library.
*ASSIST at an upcoming medical convention to help educate physicians on porphyria and/or ask your hospital or doctor if there is a local meeting where you can hand out materials. Lana Spoto, Janie Williams, Molly Buffington, Craig Humphries, Jessica Melton and her Dad, manned the exhibit booths at the Association for the Study of Liver Disease and American Society of Hematology medical conventions. You can do the same at this year’s meetings.
*VOLUNTEER your talents to help achieve the educational programs of the APF. Our talents are varied and plentiful and can be used to help one another. For example, you might want to donate one of your paintings, sculpture, weaving, etc. for our fall raffle. An anonymous donor sent the APF one of his paintings.
*VOLUNTEER your skills, like computer expertise, business acumen, or other skills to help achieve the educational programs of the APF. Computer expert, Rob Saupe, helped us with complex computer technical issues.
*HOLD a community race, car wash or other fund raising activity. Clarita Kimball and Lauren Warren raced in “Night Runs” to enhance porphyria awareness. Wyatt King entered a Box Car race for porphyria.
*HONOR your loved one with a gift to the APF for a birthday, anniversary, holiday or memorial gift, like Dr. Susan Engel did to honor Bill Kasper and Linda M Pisciotta to honor Dr. Rebecca Corley; Here is one of the most unique ways . Kate Ruby purchased 200 APF wrist bands to put in the favor baskets for each guest at her wedding to honor her aunt. More about the bride and groom and her aunt with porphyria story in the June newsletter .
*WRITE a letter to your friends and family asking them to make a donation like, Ralph Gray or vote for your pet in the Pet Beauty Contest, which will advance Physician Education and add some fun to our lives.
The APF can help you accomplish this goal by providing materials for your project:

Porphyria Brochures

A Porphyria Live DVD
Fact sheets
A Powerpoint Presentation
Information for Grand Rounds
Ideas to set up Medical Seminars
Ideas to exhibit at a Health Fair
Information to gain press
Press Releases

What is δ-Aminolevulinic Acid Dehydratase Porphyria (ADP)?

What is δ-Aminolevulinic Acid Dehydratase Porphyria (ADP)? ADP is more severe than the other acute porphyrias and can present in childhoo...