Monday, June 11, 2012

Read about the HEME POOL Taken from the APF



Imagine that the pathway is actually a river of porphyrins
and porphyrin substances which together flow into and
make up a big red-coloured pool called the Heme Pool. Like
a recipe, various ingredients (or porphyrin substances) are
added to this "river" at various stages to form the Heme
Pool. Along this river there are several gates (which represent
different stages of the Heme Pathway). These gates must
be opened fully by an operator in order to keep the proper
flow of the river into the Heme Pool. Each gate has a different
operator that has a unique key (which we'll call an
Enzyme Key) for the gate that he must open. The job of each
operator is to insert their Enzyme Key into their gate, and to
turn the key fully so that their gate will only open part way,
thus decreasing the flow of the river, resulting in a lower
level in the Heme Pool.
One day the operator at the third gate comes to work and
is not feeling well. Because of past incidences, we know that
when he wasn't well, he had taken medications that didn't
agree with him; drank alcohol; didn't eat all day; or got too
much sun. One or two of these things seemed to affect how
he did his job…specifically how far he could turn the
Enzyme Key in the gate. When he had exposure to these
"irritants" before, it could not open fully. Regardless, he still
has to go to work, since no one else can operate his gate.
Unfortunately, because his gate doesn't open fully, the flow
of porphyrins start the Pool to tell the first gate operator to
turn up the porphyrin tap to increase flow. "Heme levels are
decreasing!" they say, not even aware that the third gate
operator isn't doing his job properly. This keeps continuing
until there is a flood at the third gate. This flood puts the
whole flow into chaos until the operator at the third gate can
get back to normal. For this particular gatekeeper in the
past, having him take sugar often helped him get back on
track. In a worst case scenario, a specialist would have to
be brought in to help get the third gate operator back to work and restore normal operations. If only he would have known to stay away from those irritants, he may not have had any problems!

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